Description:
S-Adenodyl-L-Methione is endogenously produced by methionine and ATP through the action of methionine adenosyltransferase, and is an important oral active methyl donor. It is an intermediate of methionine metabolism pathway and has the functions of coenzyme, micronutrient, human metabolite, saccharomyces cerevisiae metabolite and cofactor, which can be used as a dietary supplement with strong antidepressant effect and used in the research of liver disease and osteoarthritis. At the same time, it plays an important role in cell growth and repair, and helps maintain hormones that affect mood and behavior.
This molecule participates in the following three types of reactions:
1. Methylation: It contributes methyl to activate molecules.
2. Synthesis of cysteine, glutathione and other sulfurous compounds.
3. Synthesis of polyamines: Cell growth, gene expression, neuronal rejuvenation, etc
Function:
1. S-Adenosyl methionine (SAM, SAMe, SAM-e) is a coenzyme involved in methyl group transfers. It is made from
adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation,
transsulfuration, and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions
occur throughout the body, most SAM is produced and consumed in the liver.
2 .The methyl group (CH3) attached to the methionine sulfur atom in SAM is chemically reactive. This allows donation
of this group to an acceptor substrate in transmethylation reactions. More than 40 metabolic reactions involve the
transfer of a methyl group from SAM to various substrates such as nucleic acids, proteins, and lipids.
3 .In bacteria, SAM is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis.
4 .Another major role of SAM is in polyamine biosynthesis. Here, SAM is decarboxylated by adenosylmethionine
decarboxylase (EC 4.1.1.50) to form S-adenosyl-5'-3-methylpropylamine. This compound then donates its
group in the biosynthesis of polyamines such as spermidine and spermine.
5 .SAM is required for cellular growth and repair. It is also involved in the biosynthesis of several hormones and
neurotransmitters that affect mood, such as dopamine and serotonin. Methyltransferases are also responsible for
the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger RNA.
6 .In the United States, SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled
SAME or SAMe). Some research has indicated that taking SAM on a regular basis help fight depression, liver
disease, and the pain of osteoarthritis. Multiple clinical trials indicate benefits for depression, some liver conditions
and osteoarthritis. All other indications are not yet proven.
| Product name |
S-Adenosyl Methionine |
| CAS |
29908-03-0 |
| MF |
C15H24N6O5S |
| MW |
398.44 |
| Test Method |
HPLC |
| Purity |
99% |
| Appearance |
White Crystalline Powder |
| Shelf life |
2 years |
| Storage |
Cool and dry place |
Audited Supplier 
Audited Supplier 
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